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of the Study 3 see Clinical Studies (14.6). Approximately 14 of the 77 pediatric patients in the 400 mg per day group who received topiramate as monotherapy in the controlled clinical trial discontinued therapy due to adverse reactions. Titrate Trokendi XR according to the following schedule: Week 1 50 mg once daily, week 2 100 mg once daily, week 3 150 mg once daily, week 4 200 mg once daily, week 5 300 mg once daily, week 6 400 mg once daily. Administration Instructions trokendi XR can be taken without regard to meals. The change in the mean 4-week migraine headache period frequency from baseline to the double-blind phase was -1.4, -2.1, and -2.4 in the immediate-release topiramate 50, 100, and 200 mg per day groups, respectively, versus -1.1 in the placebo group (see Figure 2 ). Trokendi XR may make your birth control pills less effective.

Additional nonspecific CNS events commonly observed with topiramate in the adjunctive epilepsy population include dizziness or ataxia. Some patients who experienced one or more cognitive-related adverse reactions in the titration phase had a dose-related recurrence of these reactions in the maintenance phase. Mutagenesis Topiramate did not demonstrate genotoxic potential when tested in a battery of in vitro and sun and ski sports discount codes in vivo assays. In most cases, symptoms and signs abated with discontinuation of either drug. Patients with other questions please call. Although there was a dose-dependent decrease in EE exposure for doses between 200 to 800 mg per day, there was no significant dose-dependent change in EE exposure for doses of 50 to 200 mg per day. If the decision is made to continue patients on topiramate in the face of persistent acidosis, alkali treatment should be considered. This difference is likely not clinically significant and probably due to the small number of patients on enzyme-inducers. Systemic exposure (AUC) of the active metabolites, 4-trans-hydroxy glyburide (M1) and 3-cis-hydroxyglyburide (M2 was also reduced by 13 and 15, reduced Cmax by 18 and 25, respectively.

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